[HTML][HTML] THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer
M Omatsu, Y Nakanishi, K Iwane, N Aoyama… - Nature …, 2023 - nature.com
… This study highlights the critical importance of bone marrow (… MTO-inoculated mice, like that
in human CRC, and its stroma-… mice into WT mice and generated GFP-BM chimeric mice for …
in human CRC, and its stroma-… mice into WT mice and generated GFP-BM chimeric mice for …
[HTML][HTML] Cell intrinsic deregulated ß-catenin signaling promotes expansion of bone marrow derived connective tissue type mast cells, systemic inflammation, and colon …
A Saadalla, MM Lima, F Tsai, A Osman… - Frontiers in …, 2019 - frontiersin.org
… performed Western blot analysis of cell extracts prepared from heterozygous 5CreCAT MCs,
… stromal localization identifies CTMCs (2–4). While we cannot rule out that tumor infiltrating …
… stromal localization identifies CTMCs (2–4). While we cannot rule out that tumor infiltrating …
[HTML][HTML] Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function
AJ Petty, R Dai, R Lapalombella, RA Baiocchi… - JCI insight, 2021 - ncbi.nlm.nih.gov
… In this study, we first showed that tumor stroma-derived PD-… PCT (qRT-PCR) using bone
marrow–derived macrophages (BMDMs) … To prepare macrophages, mice were sacrificed and …
marrow–derived macrophages (BMDMs) … To prepare macrophages, mice were sacrificed and …
The role of NK cells and CD39 in the immunological control of tumor metastases
… in CD39 expression in bone marrow-derived cells. POM-1 was … tumor-infiltrating immune
cells – particularly Treg, effector T … harvested and single cell suspensions were prepared. The …
cells – particularly Treg, effector T … harvested and single cell suspensions were prepared. The …
[HTML][HTML] … -Specific CD8+ T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating …
EM Zawidzka, L Biavati, A Thomas, C Zanettini… - bioRxiv, 2023 - ncbi.nlm.nih.gov
… Strategies employing adoptive cell therapy (ACT) have seen the establishment of chimeric …
tumor injection, bone marrow was harvested from 5 mice, processed, and prepared for sorting…
tumor injection, bone marrow was harvested from 5 mice, processed, and prepared for sorting…
[HTML][HTML] Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment
D Umezu, N Okada, Y Sakoda, K Adachi… - Cancer Immunology …, 2019 - Springer
… Experiments using bone marrow (BM) chimeric mice, … Tumor-infiltrating immune cells were
separated from tumor … were prepared and statistical differences were analyzed using the log-…
separated from tumor … were prepared and statistical differences were analyzed using the log-…
[HTML][HTML] Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy
… but is absent in bone marrow derived dendritic cells (BMDCs), … vivo function analysis of
B16-GMCSF tumor-infiltrating T cells … of mouse and human Siglec-15, cDNAs were prepared from …
B16-GMCSF tumor-infiltrating T cells … of mouse and human Siglec-15, cDNAs were prepared from …
Aptamers against mouse and human tumor-infiltrating myeloid cells as reagents for targeted chemotherapy
… to the genetically stable tumor stromal cells that characterize primary tumor, … We stained
single-cell suspensions from tumor, bone marrow… Because aptamer formulation can affect their …
single-cell suspensions from tumor, bone marrow… Because aptamer formulation can affect their …
Lead in synergism with IFNγ acts on bone marrow-resident macrophages to increase the quiescence of hematopoietic stem cells
… Functional analyses demonstrated that wild-type mice treated … the BM under a competitive
chimeric microenvironment of lethally … of cells such as osteoblasts, mesenchymal stromal cells, …
chimeric microenvironment of lethally … of cells such as osteoblasts, mesenchymal stromal cells, …
[HTML][HTML] Functionally and metabolically divergent melanoma-associated macrophages originate from common bone-marrow precursors
… we previously showed that stromal and tumor cells shape the … processes in tumor-infiltrating
immune cells could be … preparation, to honor Oscar Colegio’s work, legacy and memory. …
immune cells could be … preparation, to honor Oscar Colegio’s work, legacy and memory. …